Homoiogenetic Neural Induction in Xenopus Chimeric Explants. (Xenopus laevis/Xenopus borealis/chimeric explants/homoiogenetic neural induction/tissue-specific monoclonal antibodies)

Neural Induction without Mesoderm in Xenopus

Calcium signalling during neural induction in Xenopus laevis embryos.

In Xenopus, experiments performed with isolated ectoderm suggest that neural determination is a 'by default' mechanism, which occurs when bone morphogenetic proteins (BMPs) are antagonized by extracellular antagonists, BMP being responsible for the determination of epidermis. However, Ca(2+) imaging of intact Xenopus embryos reveals patterns of Ca(2+) transients which are generated via the acti...

Histological features of neural induction in Xenopus laevis.

It was first established by grafting experiments that neural induction occurs in Xenopus laevis and that it is the mesoderm in the dorsal lip of the blastopore which normally exercises this function. The subsequent histological work provided the following information: At stage 10i mesodermal invagination was already well under way, in advance of the formation of the archenteric cavity. This con...

Dorsal-ventral patterning and neural induction in Xenopus embryos.

We review the current status of research in dorsal-ventral (D-V) patterning in vertebrates. Emphasis is placed on recent work on Xenopus, which provides a paradigm for vertebrate development based on a rich heritage of experimental embryology. D-V patterning starts much earlier than previously thought, under the influence of a dorsal nuclear -Catenin signal. At mid-blastula two signaling center...

Neural tube closure in Xenopus

Neurulation is the process by which progenitors of the central nervous system are shaped, separated from and brought beneath the epidermis. The cellular basis of these movements have been investigated in amphibians (Jacobson, 1981; Jacobson and Gordon, 1976; Keller et al., 1992b), chicken (Schoenwolf and Smith, 1990b; Smith and Schoenwolf, 1997) and mice (Bush et al., 1990; Sausedo and Schoenwo...